Cayenne stimulates the nervous system, awakens mucus, and can cause the heart to beat faster. The heat builds on itself. Jeffries likes to say that hot chicken will sober you up and clean you out. She calls it “a twenty-four-hour chicken.” Activities that may not pair well with Nashville hot chicken include a road trip, a long flight, a first date, work, sleep, and your wedding. First-timers have been advised to prepare for hot chicken by putting a roll of toilet paper in the freezer at home.